Side Effects of Dimethyl Sulphoxide
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چکیده
منابع مشابه
Use of Dimethyl Sulphoxide for Preserving Corneal
SINCE it was discovered by Polge, Smith, and Parkes (1949) that living cells could be protected during freezing and thawing by adding glycerol to the storage medium, various substances and methods have been used in an attempt to achieve better results (Fleming,: 1952; Eastcott, Cross, Leigh, and North, 1954; Lovelock, 1954). We have been concerned with retaining the viability of corneal tissue ...
متن کاملBacterial dimethyl sulphoxide reductases and nitrate reductases.
interactions which can be done when more structural information is available, but they do provide order of magnitude estimates of interaction strengths. Evidently, considerable rearrangement of charge driven by reduction significantly raises the effective dielectric. It seems likely that centres S-2 and FR-2 are apparently low-potential clusters merely because they are the middle clusters in th...
متن کاملCongenital malformations induced by dimethyl sulphoxide in the golden hamster.
Dimethyl sulphoxide (DMSO) is a relatively simple organic compound with a molecular weight of 78. It has been reported to be exceptionally non-toxic and has been used extensively in biological systems as a cell preservative, including freeze storage (Porterfield & Ashwood-Smith, 1962; Dougherty, 1962), and as a radioprotective agent against X-irradiation in mice (Ashwood-Smith, 1961). Recent cl...
متن کاملDimethyl sulphoxide protects cells against polypeptide toxins and poliovirus.
The effect of dimethyl sulphoxide and other cryoprotective compounds on the sensitivity of cells to polypeptide toxins and to poliovirus was tested. In the presence of these compounds, which all affect membrane fluidity, the cells were protected against the toxic proteins and against poliovirus. The large protection obtained was not due to reduced binding and endocytosis of the toxins. Apparent...
متن کاملDimethyl sulphoxide enhances the effects of P(i) in myofibrils and inhibits the activity of rabbit skeletal muscle contractile proteins.
In the catalytic cycle of skeletal muscle, myosin alternates between strongly and weakly bound cross-bridges, with the latter contributing little to sustained tension. Here we describe the action of DMSO, an organic solvent that appears to increase the population of weakly bound cross-bridges that accumulate after the binding of ATP, but before P(i) release. DMSO (5-30%, v/v) reversibly inhibit...
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ژورنال
عنوان ژورنال: Nature
سال: 1967
ISSN: 0028-0836,1476-4687
DOI: 10.1038/2151168a0